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Biogenex antibodies with IVD CE marking
New Biogenex antibodies with IVD CE Marking
Biogenex is pleased to announce the release of the following new antibodies with IVD CE Marking:
1. Anti – ACTH (Mouse Monoclonal)
2. Anti – Cyclin D1 (Rabbit Monoclonal)
3. Anti – CD3 Epsilon (Rabbit Monoclonal)
4. Anti – Alk/p80 (Rabbit Monoclonal)
5. Anti – Stat5-Alpha (Rabbit Monoclonal)
6. Anti – GCDFP-15 (Rabbit Monoclonal)
7. Anti – CD61 (Rabbit Monoclonal)
Each of the above antibodies is available in 1ml Concentrated, 6ml Ready-to-Use (Manual) and 10ml Ready-to-Use (Automated) Formats.
ACTH:
Adrenocorticotropic hormone (ACTH or Corticotropin) is a polypeptide tropic hormone
produced and secreted by the anterior pituitary gland. It is an important component of
the hypothalamic-pituitary-adrenal axis and is often produced in response to biological
stress (along with corticotrophin-releasing hormone from the hypothalamus).
Its principal effects are increased production of androgens and as its name suggests,
cortisol from the adrenal cortex.
It labels corticotrophs in the adenohypophysis and is useful in the classification of
pituitary adenomas.
Cyclin D1:
Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S
transition. Cyclin D1 forms a serine/threonine kinase holoenzyme complex with and
functions as a regulatory subunit of CDK4 or CDK6.
Cyclin D1 phosphorylates and inactivates the retinoblastoma protein and promotes
progression through the G1/S phase.
Amplification of overexpression of Cyclin D1 plays a pivotal role in the development of
various human tumors including parathyroid adenoma, breast tumor, colon tumor,
lymphoma, melanoma and prostate tumor.
Cyclin D1 also associates with and regulates the activity of transcription factors,
coactivators and corepressors that govern histone acetylation and chromatin remodeling
proteins.
CD3 Epsilon:
CD3 (Cluster of Differentiation 3) is a complex of proteins that associates directly with the T cell
antigen receptor (TCR) (1). Antigen binding to the TCR leads to IL-2 secretion via activation of a
tyrosine phosphorylation pathway and a phospholipase C (PLC) pathway, in turn activating
protein kinase C (1,2).
CD3 is composed of five invariant polypeptide chains that associate to form three dimers. The
five invariant chains of CD3 are labelled gamma, delta, epsilon, zeta and eta. The gamma,
epsilon and delta chains each contain a single copy of a conserved immunoreceptor tyrosinebased
activation motif(ITAM). Phosphorylated ITAMS act as docking sites for protein kinases
such as ZAP-70 and Syk (3).
CD3 is an important marker for Mature T Cells and T Cell Lymphomas.
Alk/p80:
ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane
domain and an extracellular domain. The 2:5 chromosomal translocation occurs in most
anaplastic large-cell non-Hodgkin's lymphomas arising from activated T lymphocytes.
This rearrangement was shown to fuse the NPM nucleolar phosphoprotein gene on
chromosome 5q35 to a previously unidentified protein tyrosine kinase gene, ALK, on
chromosome 2p23. In the predicted hybrid protein, the amino terminus of NPM is linked
to the catalytic domain of ALK.
Immunoblotting with anti-ALK antibody shows that ALK is highly expressed in the
neonatal brain.
Alk is an useful marker in Anaplastic Large Cell tumors.
Unscheduled expression of the truncated ALK may contribute to malignant
transformation in these lymphomas.
Alk/p80 is also expressed in the small intestine, testis and brain, but not in normal
lymphoid cells, ALK shows greatest sequence similarity to the insulin receptor subfamily
of kinases.
Stat5-Alpha:
Stat5 is part of a 7 protein family known as signal transducer and activator of
transcription (STAT) which contributes to signal transduction by cytokine, hormone and
growth factor.
Signal transducer and activator of transcription 5 (Stat5) functions both in signal
translocated to the nucleus in response to phosphorylation.
Stat-alpha tyrosine phosphorylation is activated predominantly by IL-2, but also by IL-3,
IL-5, IL-7, IL-9, IL-15, G-CSF and GM-CSF. Tyrosine phosphorylation is required for
maximal transcriptional activity. NCoA-1/SRC-1 acts as coactivator for both the alpha
and beta isoforms of Stat5.
Stat5-Alpha is an useful marker in Squamous Cell Lung tumors.
GCDFP-15:
The androgen and prolactin responsive prolactin-inducible protein (PIP)/gross cystic
disease fluid protein (GCDFP-15) is expressed in human breast tumors and in such
normal exocrine organs as sweat, salivary and lacrimal glands.
The hormonally responsive prolactin-inducible protein (PIP) gene is expressed in breast
tumor tissues and in such normal exocrine organs as sweat, salivary and lacrimal
glands.
CD61/ Integrin β-3A:
Platelet membrane glycoprotein Integrin ß-3 (GP IIIa) forms a Ca2+-dependent
heterodimer complex with GP IIb. The GP IIb-IIIa complex constitutes the fibrinogen
and fibronectin receptor on stimulated platelets.
A biochemically and immunologically similar member glycoprotein complex is present on
endothelial cells.
Homology suggests that GP IIIa is a member of a family of cell-surface adhesion
receptors.
Data provide further support for the key role of the cytoplasmic domain of the ß-3
integrin in cell adhesion and suggest a potential role for the ß-3C integrin subunit in
modulating cell-matrix interactions. It has been demonstrated that the ß-3 subunit of
alpha IIb ß-3 was phosphorylated on tyrosine residues in response to thrombin-induced
platelet aggregation.
Data suggest that tyrosine phosphorylation of an integrin beta subunit may be
important in initiating outside-in signaling cascades by inducing association of signaling
components directly with the integrin.
Biogenex is pleased to announce the release of the following new antibodies with IVD CE Marking:
1. Anti – ACTH (Mouse Monoclonal)
2. Anti – Cyclin D1 (Rabbit Monoclonal)
3. Anti – CD3 Epsilon (Rabbit Monoclonal)
4. Anti – Alk/p80 (Rabbit Monoclonal)
5. Anti – Stat5-Alpha (Rabbit Monoclonal)
6. Anti – GCDFP-15 (Rabbit Monoclonal)
7. Anti – CD61 (Rabbit Monoclonal)
Each of the above antibodies is available in 1ml Concentrated, 6ml Ready-to-Use (Manual) and 10ml Ready-to-Use (Automated) Formats.
ACTH:
Adrenocorticotropic hormone (ACTH or Corticotropin) is a polypeptide tropic hormone
produced and secreted by the anterior pituitary gland. It is an important component of
the hypothalamic-pituitary-adrenal axis and is often produced in response to biological
stress (along with corticotrophin-releasing hormone from the hypothalamus).
Its principal effects are increased production of androgens and as its name suggests,
cortisol from the adrenal cortex.
It labels corticotrophs in the adenohypophysis and is useful in the classification of
pituitary adenomas.
Cyclin D1:
Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S
transition. Cyclin D1 forms a serine/threonine kinase holoenzyme complex with and
functions as a regulatory subunit of CDK4 or CDK6.
Cyclin D1 phosphorylates and inactivates the retinoblastoma protein and promotes
progression through the G1/S phase.
Amplification of overexpression of Cyclin D1 plays a pivotal role in the development of
various human tumors including parathyroid adenoma, breast tumor, colon tumor,
lymphoma, melanoma and prostate tumor.
Cyclin D1 also associates with and regulates the activity of transcription factors,
coactivators and corepressors that govern histone acetylation and chromatin remodeling
proteins.
CD3 Epsilon:
CD3 (Cluster of Differentiation 3) is a complex of proteins that associates directly with the T cell
antigen receptor (TCR) (1). Antigen binding to the TCR leads to IL-2 secretion via activation of a
tyrosine phosphorylation pathway and a phospholipase C (PLC) pathway, in turn activating
protein kinase C (1,2).
CD3 is composed of five invariant polypeptide chains that associate to form three dimers. The
five invariant chains of CD3 are labelled gamma, delta, epsilon, zeta and eta. The gamma,
epsilon and delta chains each contain a single copy of a conserved immunoreceptor tyrosinebased
activation motif(ITAM). Phosphorylated ITAMS act as docking sites for protein kinases
such as ZAP-70 and Syk (3).
CD3 is an important marker for Mature T Cells and T Cell Lymphomas.
Alk/p80:
ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane
domain and an extracellular domain. The 2:5 chromosomal translocation occurs in most
anaplastic large-cell non-Hodgkin's lymphomas arising from activated T lymphocytes.
This rearrangement was shown to fuse the NPM nucleolar phosphoprotein gene on
chromosome 5q35 to a previously unidentified protein tyrosine kinase gene, ALK, on
chromosome 2p23. In the predicted hybrid protein, the amino terminus of NPM is linked
to the catalytic domain of ALK.
Immunoblotting with anti-ALK antibody shows that ALK is highly expressed in the
neonatal brain.
Alk is an useful marker in Anaplastic Large Cell tumors.
Unscheduled expression of the truncated ALK may contribute to malignant
transformation in these lymphomas.
Alk/p80 is also expressed in the small intestine, testis and brain, but not in normal
lymphoid cells, ALK shows greatest sequence similarity to the insulin receptor subfamily
of kinases.
Stat5-Alpha:
Stat5 is part of a 7 protein family known as signal transducer and activator of
transcription (STAT) which contributes to signal transduction by cytokine, hormone and
growth factor.
Signal transducer and activator of transcription 5 (Stat5) functions both in signal
translocated to the nucleus in response to phosphorylation.
Stat-alpha tyrosine phosphorylation is activated predominantly by IL-2, but also by IL-3,
IL-5, IL-7, IL-9, IL-15, G-CSF and GM-CSF. Tyrosine phosphorylation is required for
maximal transcriptional activity. NCoA-1/SRC-1 acts as coactivator for both the alpha
and beta isoforms of Stat5.
Stat5-Alpha is an useful marker in Squamous Cell Lung tumors.
GCDFP-15:
The androgen and prolactin responsive prolactin-inducible protein (PIP)/gross cystic
disease fluid protein (GCDFP-15) is expressed in human breast tumors and in such
normal exocrine organs as sweat, salivary and lacrimal glands.
The hormonally responsive prolactin-inducible protein (PIP) gene is expressed in breast
tumor tissues and in such normal exocrine organs as sweat, salivary and lacrimal
glands.
CD61/ Integrin β-3A:
Platelet membrane glycoprotein Integrin ß-3 (GP IIIa) forms a Ca2+-dependent
heterodimer complex with GP IIb. The GP IIb-IIIa complex constitutes the fibrinogen
and fibronectin receptor on stimulated platelets.
A biochemically and immunologically similar member glycoprotein complex is present on
endothelial cells.
Homology suggests that GP IIIa is a member of a family of cell-surface adhesion
receptors.
Data provide further support for the key role of the cytoplasmic domain of the ß-3
integrin in cell adhesion and suggest a potential role for the ß-3C integrin subunit in
modulating cell-matrix interactions. It has been demonstrated that the ß-3 subunit of
alpha IIb ß-3 was phosphorylated on tyrosine residues in response to thrombin-induced
platelet aggregation.
Data suggest that tyrosine phosphorylation of an integrin beta subunit may be
important in initiating outside-in signaling cascades by inducing association of signaling
components directly with the integrin.