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New Monosan Multidrug Resistance Antibodies
New Monosan Multidrug Resistance Antibodies
Chemotherapy has many advances in the treatment of disseminated tumors and although it is quite effective in treating certain cancers, most other types of cancer respond to chemotherapy poorly or partially. Failure of chemotherapeutic regimen may be due to different factors including the inability of the drug to reach the tumor site. Tumor cell that are insensitive to anticancer drugs frequently have a multidrug resistance MDR phenotype. The MRP gene product, Multidrug Resistance-associated protein has been shown to confer a similar resistance phenotype. The understanding of these mechanisms is fundamental to develop strategies aimed to prevent or circumvent resistance, thus improving the results of chemotherapy.
Cat. MON9123, Moab x MRP5 (ABCC5), clone M5I-10
Price: 9.978Kč
Size: 1 ml vials (>>200 tests) containing antibody in serumfree culture supernatant, with 0.7% BSA and 0.1% sodium azide.
Concentration: 250 μg immunoglobulin/ml (by ELISA)
Use: The antibody is useful for immunocytochemistry (acetone fixed cytospin preparations), immunohistochemisty on frozen sections and Western blotting.
Literature:
1) Multidrug resistance-associated proteins 3, 4, and 5. Borst P, de Wolf C, van de Wetering K.Pflugers Arch. 2007 Feb;453(5):661-73.
2) The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites. Pratt S, Shepard RL, Kandasamy RA, Johnston PA, Perry W 3rd, Dantzig AH.Mol Cancer Ther. 2005 May;4(5):855-63.
3) Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Reid G, Wielinga P, Zelcer N, De Haas M, Van Deemter L, Wijnholds J, Balzarini J, Borst P.Mol Pharmacol. 2003 May;63(5):1094-103.
4) Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5 and MDR3 P-glycoprotein with a panel of monoclonal antibodies. Scheffer et al. Cancer Res 60: 5269, 2000.
5) Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologs of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Kool et al. Cancer Res 57: 3537-3547, 1997.
Cat. MON9124, Moab x MRP7 (ABCC10), clone M7I-3
Price: 9.978Kč
Size: 1 ml vials (>>200 tests) containing antibody in serumfree culture supernatant, with 0.7% BSA and 0.1% sodium azide.
Concentration: 250 μg immunoglobulin/ml (by ELISA)
Use: The antibody is useful for immunocytochemistry (acetone fixed cytospin preparations), immunohistochemisty on frozen sections and Western blotting.
Literature:
1) Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity
of the MRP7 (ABCC10). Shen T, Kuang YH, Ashby CR, Lei Y, Chen A, Zhou Y, Chen X, Tiwari AK,
opper-Borge E, Ouyang J, Chen ZS. PLoS One. 2009 Oct 20;4(10)
2) Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B. Hopper-Borge E, Xu X, Shen T, Shi Z, Chen ZS, Kruh GD. Cancer Res. 2009 Jan 1;69(1):178-84.
3) ABCC10/MRP7 is associated with vinorelbine resistance in non-small cell lung cancer. Bessho Y, Oguri T, Ozasa H, Uemura T, Sakamoto H, Miyazaki M, Maeno K, Sato S, Ueda R. Oncol Rep. 2009 Jan;21(1):263-8.
4) Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel. Hopper-Borge E, Chen ZS, Shchaveleva I, Belinsky MG, Kruh GD. Cancer Res. 2004 Jul 15;64(14):4927-30.
Cat. MON9120, Moab x MRP8 (ABCC11), clone M8I-74
Price: 9.978Kč
Size: 1 ml vials (>>200 tests) containing antibody in serumfree culture supernatant, with 0.7% BSA and 0.1% sodium azide.
Concentration: 250 μg immunoglobulin/ml (by ELISA)
Use: The antibody is useful for immunocytochemistry (acetone fixed cytospin preparations), immunohistochemisty on frozen sections and Western blotting.
Literature:
1) ABCC10, ABCC11, and ABCC12. Kruh GD, Guo Y, Hopper-Borge E, Belinsky MG, Chen ZS.
Pflugers Arch. 2007 Feb;453(5):675-84
2) cGMP transport by vesicles from human and mouse erythrocytes. de Wolf CJ, Yamaguchi H, van der Heijden I, Wielinga PR, Hundscheid SL, Ono N, Scheffer GL, de Haas M, Schuetz JD, Wijnholds J, Borst P. FEBS J. 2007 Jan;274(2):439-50
3) MRP8/ABCC11 directly confers resistance to 5-fluorouracil. Oguri T, Bessho Y, Achiwa H, Ozasa H, Maeno K, Maeda H, Sato S, Ueda R. Mol Cancer Ther. 2007 Jan;6(1):122-7
4) Gene expression profiling of ATP-binding cassette (ABC) transporters as a predictor of the pathologic response to neoadjuvant chemotherapy in breast cancer patients. Park S, Shimizu C,
5) Shimoyama T, Takeda M, Ando M, Kohno T, Katsumata N, Kang YK, Nishio K, Fujiwara Y. Breast Cancer Res Treat. 2006 Sep;99(1):9-17.
6) A SNP in the ABCC11 gene is the determinant of human earwax type. Yoshiura K, Kinoshita A, Ishida T, et al. Nat Genet. 2006 Mar;38(3):324-30.
Cat. MON9121, Moab x MRP9 (ABCC12), clone M9I-38
Price: 9.978Kč
Size: 1 ml vials (>>200 tests) containing antibody in serumfree culture supernatant, with 0.7% BSA and 0.1% sodium azide.
Concentration: 250 μg immunoglobulin/ml (by ELISA)
Use: The antibody is useful for immunocytochemistry (acetone fixed cytospin preparations), immunohistochemisty on frozen sections and Western blotting.
Literature:
1) Multidrug resistance-associated protein 9 (ABCC12) is present in mouse and boar sperm.
Ono N, Van der Heijden I, Scheffer GL, Van de Wetering K, Van Deemter E, De Haas M, Boerke A, Gadella BM, De Rooij DG, Neefjes JJ, Groothuis TA, Oomen L, Brocks L, Ishikawa T, Borst P.
Biochem J. 2007 Aug 15;406(1):31-40.
2) ABCC10, ABCC11, and ABCC12. Kruh GD, Guo Y, Hopper-Borge E, Belinsky MG, Chen ZS.
Pflugers Arch. 2007 Feb;453(5):675-84. Epub 2006 Jul 26.
3) MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer. Bera TK, Iavarone C, Kumar V, Lee S, Lee B, Pastan I. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6997-7002.
Cat. MON9122, Moab x MRP9 (ABCC12), clone M9II-3
Price: 9.978Kč
Size: 1 ml vials (>>200 tests) containing antibody in serumfree culture supernatant, with 0.7% BSA and 0.1% sodium azide.
Concentration: 250 μg immunoglobulin/ml (by ELISA)
Use: The antibody is useful for immunocytochemistry (acetone fixed cytospin preparations), immunohistochemisty on frozen sections and Western blotting.
Literature:
1) Multidrug resistance-associated protein 9 (ABCC12) is present in mouse and boar sperm.
Ono N, Van der Heijden I, Scheffer GL, Van de Wetering K, Van Deemter E, De Haas M, Boerke A, Gadella BM, De Rooij DG, Neefjes JJ, Groothuis TA, Oomen L, Brocks L, Ishikawa T, Borst P.
Biochem J. 2007 Aug 15;406(1):31-40.
2) ABCC10, ABCC11, and ABCC12. Kruh GD, Guo Y, Hopper-Borge E, Belinsky MG, Chen ZS.
Pflugers Arch. 2007 Feb;453(5):675-84. Epub 2006 Jul 26.
3) MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer. Bera TK, Iavarone C, Kumar V, Lee S, Lee B, Pastan I. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6997-7002.
Chemotherapy has many advances in the treatment of disseminated tumors and although it is quite effective in treating certain cancers, most other types of cancer respond to chemotherapy poorly or partially. Failure of chemotherapeutic regimen may be due to different factors including the inability of the drug to reach the tumor site. Tumor cell that are insensitive to anticancer drugs frequently have a multidrug resistance MDR phenotype. The MRP gene product, Multidrug Resistance-associated protein has been shown to confer a similar resistance phenotype. The understanding of these mechanisms is fundamental to develop strategies aimed to prevent or circumvent resistance, thus improving the results of chemotherapy.
Cat. MON9123, Moab x MRP5 (ABCC5), clone M5I-10
Price: 9.978Kč
Size: 1 ml vials (>>200 tests) containing antibody in serumfree culture supernatant, with 0.7% BSA and 0.1% sodium azide.
Concentration: 250 μg immunoglobulin/ml (by ELISA)
Use: The antibody is useful for immunocytochemistry (acetone fixed cytospin preparations), immunohistochemisty on frozen sections and Western blotting.
Literature:
1) Multidrug resistance-associated proteins 3, 4, and 5. Borst P, de Wolf C, van de Wetering K.Pflugers Arch. 2007 Feb;453(5):661-73.
2) The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites. Pratt S, Shepard RL, Kandasamy RA, Johnston PA, Perry W 3rd, Dantzig AH.Mol Cancer Ther. 2005 May;4(5):855-63.
3) Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Reid G, Wielinga P, Zelcer N, De Haas M, Van Deemter L, Wijnholds J, Balzarini J, Borst P.Mol Pharmacol. 2003 May;63(5):1094-103.
4) Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5 and MDR3 P-glycoprotein with a panel of monoclonal antibodies. Scheffer et al. Cancer Res 60: 5269, 2000.
5) Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologs of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Kool et al. Cancer Res 57: 3537-3547, 1997.
Cat. MON9124, Moab x MRP7 (ABCC10), clone M7I-3
Price: 9.978Kč
Size: 1 ml vials (>>200 tests) containing antibody in serumfree culture supernatant, with 0.7% BSA and 0.1% sodium azide.
Concentration: 250 μg immunoglobulin/ml (by ELISA)
Use: The antibody is useful for immunocytochemistry (acetone fixed cytospin preparations), immunohistochemisty on frozen sections and Western blotting.
Literature:
1) Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity
of the MRP7 (ABCC10). Shen T, Kuang YH, Ashby CR, Lei Y, Chen A, Zhou Y, Chen X, Tiwari AK,
opper-Borge E, Ouyang J, Chen ZS. PLoS One. 2009 Oct 20;4(10)
2) Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B. Hopper-Borge E, Xu X, Shen T, Shi Z, Chen ZS, Kruh GD. Cancer Res. 2009 Jan 1;69(1):178-84.
3) ABCC10/MRP7 is associated with vinorelbine resistance in non-small cell lung cancer. Bessho Y, Oguri T, Ozasa H, Uemura T, Sakamoto H, Miyazaki M, Maeno K, Sato S, Ueda R. Oncol Rep. 2009 Jan;21(1):263-8.
4) Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel. Hopper-Borge E, Chen ZS, Shchaveleva I, Belinsky MG, Kruh GD. Cancer Res. 2004 Jul 15;64(14):4927-30.
Cat. MON9120, Moab x MRP8 (ABCC11), clone M8I-74
Price: 9.978Kč
Size: 1 ml vials (>>200 tests) containing antibody in serumfree culture supernatant, with 0.7% BSA and 0.1% sodium azide.
Concentration: 250 μg immunoglobulin/ml (by ELISA)
Use: The antibody is useful for immunocytochemistry (acetone fixed cytospin preparations), immunohistochemisty on frozen sections and Western blotting.
Literature:
1) ABCC10, ABCC11, and ABCC12. Kruh GD, Guo Y, Hopper-Borge E, Belinsky MG, Chen ZS.
Pflugers Arch. 2007 Feb;453(5):675-84
2) cGMP transport by vesicles from human and mouse erythrocytes. de Wolf CJ, Yamaguchi H, van der Heijden I, Wielinga PR, Hundscheid SL, Ono N, Scheffer GL, de Haas M, Schuetz JD, Wijnholds J, Borst P. FEBS J. 2007 Jan;274(2):439-50
3) MRP8/ABCC11 directly confers resistance to 5-fluorouracil. Oguri T, Bessho Y, Achiwa H, Ozasa H, Maeno K, Maeda H, Sato S, Ueda R. Mol Cancer Ther. 2007 Jan;6(1):122-7
4) Gene expression profiling of ATP-binding cassette (ABC) transporters as a predictor of the pathologic response to neoadjuvant chemotherapy in breast cancer patients. Park S, Shimizu C,
5) Shimoyama T, Takeda M, Ando M, Kohno T, Katsumata N, Kang YK, Nishio K, Fujiwara Y. Breast Cancer Res Treat. 2006 Sep;99(1):9-17.
6) A SNP in the ABCC11 gene is the determinant of human earwax type. Yoshiura K, Kinoshita A, Ishida T, et al. Nat Genet. 2006 Mar;38(3):324-30.
Cat. MON9121, Moab x MRP9 (ABCC12), clone M9I-38
Price: 9.978Kč
Size: 1 ml vials (>>200 tests) containing antibody in serumfree culture supernatant, with 0.7% BSA and 0.1% sodium azide.
Concentration: 250 μg immunoglobulin/ml (by ELISA)
Use: The antibody is useful for immunocytochemistry (acetone fixed cytospin preparations), immunohistochemisty on frozen sections and Western blotting.
Literature:
1) Multidrug resistance-associated protein 9 (ABCC12) is present in mouse and boar sperm.
Ono N, Van der Heijden I, Scheffer GL, Van de Wetering K, Van Deemter E, De Haas M, Boerke A, Gadella BM, De Rooij DG, Neefjes JJ, Groothuis TA, Oomen L, Brocks L, Ishikawa T, Borst P.
Biochem J. 2007 Aug 15;406(1):31-40.
2) ABCC10, ABCC11, and ABCC12. Kruh GD, Guo Y, Hopper-Borge E, Belinsky MG, Chen ZS.
Pflugers Arch. 2007 Feb;453(5):675-84. Epub 2006 Jul 26.
3) MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer. Bera TK, Iavarone C, Kumar V, Lee S, Lee B, Pastan I. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6997-7002.
Cat. MON9122, Moab x MRP9 (ABCC12), clone M9II-3
Price: 9.978Kč
Size: 1 ml vials (>>200 tests) containing antibody in serumfree culture supernatant, with 0.7% BSA and 0.1% sodium azide.
Concentration: 250 μg immunoglobulin/ml (by ELISA)
Use: The antibody is useful for immunocytochemistry (acetone fixed cytospin preparations), immunohistochemisty on frozen sections and Western blotting.
Literature:
1) Multidrug resistance-associated protein 9 (ABCC12) is present in mouse and boar sperm.
Ono N, Van der Heijden I, Scheffer GL, Van de Wetering K, Van Deemter E, De Haas M, Boerke A, Gadella BM, De Rooij DG, Neefjes JJ, Groothuis TA, Oomen L, Brocks L, Ishikawa T, Borst P.
Biochem J. 2007 Aug 15;406(1):31-40.
2) ABCC10, ABCC11, and ABCC12. Kruh GD, Guo Y, Hopper-Borge E, Belinsky MG, Chen ZS.
Pflugers Arch. 2007 Feb;453(5):675-84. Epub 2006 Jul 26.
3) MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer. Bera TK, Iavarone C, Kumar V, Lee S, Lee B, Pastan I. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6997-7002.