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Monosan antibodies
NEW Monosan Products:
Proprietary mouse anti-citrulline antibodies
In Rheumatoid Arthritis and Multiple Sclerosis citrullination of various proteins has been suggested to play a major role in the ontogeny of these diseases. The availability of anti-citrulline antibodies for analysing diseased tissue and cells might open new methods for research towards these diseases.
Citrullinated Fibrinogen, clone 3D1 100 ug MON9093
Citrullinated Fibrinogen, clone 20B2 100 ug MON9094
Citrullinated Fibrinogen, clone 4.19D5 100 ug MON9095
Citrullinated Fibrinogen, clone 23H2 100 ug MON9096
Citrullinated Fibrinogen, clone 3F2 100 ug MON9102
Peptidyl Arginine Deiminase (PAD) enzyme products
PAD enzymes are transcriptional co-regulators that catalyze the calcium dependent conversion of specific arginine residues, present in for example histones and other proteins, to citrulline. In diseases such as Multiple Sclerosis and Rheumatoid Arthritis (RA) PAD enzymes seem to
be deregulated. For instance in RA, these enzymes become active when they exit the cell in regions of joint inflammation where they subsequently deiminate arginine residues present in proteins such as vimentin and fibrinogen. The level of PAD activity has been correlated with RA severity.
mPAD4 10 units MON9106
hPAD2 10 units MON9107
hPAD4 10 units MON9108
Collagen Antibody Induced Arthritis (CAIA) mouse model for Rheumatoid Arthritis
An efficient mix of anti-collagen antibodies, for the generation of a Collagen Antibody Induced Arthritis (CAIA) mouse animal model. This CAIA model is ideal for rapidly screening novel arthritis therapeutics and to study the mechanisms involved in the development of arthritis. The CAIA antibodies can be delivered directly to clients for in-house animal generation. Alternatively, under collaboration with third parties complete animal studies using these CAIA antibodies are offered by Monosan.
Mouse Collagen II CAIA 50mg MON9109
Proprietary mouse anti-citrulline antibodies
In Rheumatoid Arthritis and Multiple Sclerosis citrullination of various proteins has been suggested to play a major role in the ontogeny of these diseases. The availability of anti-citrulline antibodies for analysing diseased tissue and cells might open new methods for research towards these diseases.
Citrullinated Fibrinogen, clone 3D1 100 ug MON9093
Citrullinated Fibrinogen, clone 20B2 100 ug MON9094
Citrullinated Fibrinogen, clone 4.19D5 100 ug MON9095
Citrullinated Fibrinogen, clone 23H2 100 ug MON9096
Citrullinated Fibrinogen, clone 3F2 100 ug MON9102
Peptidyl Arginine Deiminase (PAD) enzyme products
PAD enzymes are transcriptional co-regulators that catalyze the calcium dependent conversion of specific arginine residues, present in for example histones and other proteins, to citrulline. In diseases such as Multiple Sclerosis and Rheumatoid Arthritis (RA) PAD enzymes seem to
be deregulated. For instance in RA, these enzymes become active when they exit the cell in regions of joint inflammation where they subsequently deiminate arginine residues present in proteins such as vimentin and fibrinogen. The level of PAD activity has been correlated with RA severity.
mPAD4 10 units MON9106
hPAD2 10 units MON9107
hPAD4 10 units MON9108
Collagen Antibody Induced Arthritis (CAIA) mouse model for Rheumatoid Arthritis
An efficient mix of anti-collagen antibodies, for the generation of a Collagen Antibody Induced Arthritis (CAIA) mouse animal model. This CAIA model is ideal for rapidly screening novel arthritis therapeutics and to study the mechanisms involved in the development of arthritis. The CAIA antibodies can be delivered directly to clients for in-house animal generation. Alternatively, under collaboration with third parties complete animal studies using these CAIA antibodies are offered by Monosan.
Mouse Collagen II CAIA 50mg MON9109